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Peptides
Semaglutide
In plain language
The active ingredient in Ozempic and Wegovy. Reduces appetite and helps with significant weight loss and blood sugar control.
Is it an approved medication?
Yes — approved medication
YES - approved by the FDA as an actual medication (Ozempic for diabetes, Wegovy for weight)
How strong is the evidence?
Very strong - dozens of large human trials
The main thing to know
Prescription-only. Common side effects are nausea and stomach upset.
Mechanism
GLP-1 receptor agonist; slows gastric emptying, increases satiety, and enhances glucose-dependent insulin secretion.
Potential benefits
- Substantial weight loss
- Cardiovascular risk reduction in patients with pre-existing CVD
- Glycemic control in type 2 diabetes
Regulatory status
FDA/EMA approved (Ozempic, Wegovy) for type 2 diabetes and chronic weight management