Peptides
Sermorelin
In plain language
An older growth-hormone peptide. It USED to be an approved medicine for children with growth hormone deficiency, but that approval was withdrawn years ago.
Hard safety warning
Not a real, regulated product — do not buy this online.
Is it an approved medication?
No longer approved
No longer - it was once FDA-approved (as Geref) but that approval was discontinued
How strong is the evidence?
Solid old evidence for its original medical use; weak for today's popular anti-aging use
The main thing to know
Today it is mostly available only through compounding pharmacies with a prescription, not as a retail product.
Mechanism
GHRH analog (fragment 1-29); stimulates endogenous pituitary GH release, historically used diagnostically and therapeutically in GH deficiency.
Potential benefits
- Established use in pediatric GH deficiency (historical)
- Popular but poorly evidenced for adult anti-aging use
Regulatory status
Previously FDA-approved (Geref, discontinued); now compounded/research use in many markets