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Peptides
Tirzepatide
In plain language
The active ingredient in Mounjaro and Zepbound. Similar to semaglutide but often produces even more weight loss.
Is it an approved medication?
Yes — approved medication
YES - approved by the FDA as an actual medication (Mounjaro for diabetes, Zepbound for weight)
How strong is the evidence?
Very strong - large human trials
The main thing to know
Prescription-only. Common side effects are nausea and stomach upset.
Mechanism
Dual GIP/GLP-1 receptor agonist; combines incretin effects for enhanced insulin secretion, satiety, and gastric emptying delay.
Potential benefits
- Weight loss (greater magnitude than GLP-1 mono-agonists)
- Glycemic control
- Cardiometabolic risk factor improvement
Regulatory status
FDA/EMA approved (Mounjaro, Zepbound) for type 2 diabetes and chronic weight management